Effect of folate supplementation on gastric tissue in INS-GAS Helicobacter felis-infected mice

ABSTRACT: Background & Aims: Previous studies have suggested that dietary folic acid (FA) can protect against certain types of cancers. However, the findings have varied and the mechanisms by which this vitamin exerts chemopreventive effects remain to be clarified. We examined the effects of FA supplementation on DNA methylation, gene expression and gastric dysplasia in a transgenic mouse model that is etiologically and histologically well matched with human gastric cancers. Methods: Hypergastrinemic mice (INS-GAS) infected with Helicobacter felis were studied at multiple stages of gastric dysplasia and early cancer, with FA supplementation initiated both at weaning and later in life. Global DNA methylation was assessed by a methylation-sensitive cytosine incorporation assay, bisulfite pyroseque

ORGANISM(S): Mus musculus

SUBMITTER: TAMAS GONDA 

PROVIDER: E-GEOD-30830 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress