Expression data from the hearts of aged Norway Brown rats (18-22 months-old)

ABSTRACT: Despite an abundance of evidence to the contrary from animal studies, large clinical trials on humans have shown that estrogen administered to post-menopausal women increases the risk of cardiovascular disease. However, timing may be everything, as estrogen is often administered immediately after ovariectomy (ovx) in animal studies, while estrogen administration in human studies occurred many years post-menopause. This study investigates the discrepancy by administering 17ß-estradiol (E2) in a slow-release capsule to Norway Brown rats both immediately following ovx and 9 weeks post-ovx (Late), and studying differences in gene expression between these 2 groups as compared to age-matched ovx and sham operated animals. Two different types of microarray were used to analyze the left ventric

ORGANISM(S): Rattus norvegicus

SUBMITTER: Li Lin 

PROVIDER: E-GEOD-30851 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress