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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Gene expression of polyoma middle T antigen induced mammary tumors [NZB x PyMT]

ABSTRACT: Mouse genetic crosses were established between the PyMT model of metastatic breast cancer and NZB strain. Tumors were harvested from the animals for gene expression analysis to identify genes and network modules associated with progression to distant metastatic disease. Gene expression of 68 samples from the NZB crosses were assayed on Affymetrix chips

ORGANISM(S): Mus musculus

SUBMITTER: Ying Hu

PROVIDER: E-GEOD-30865 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Gene expression of polyoma middle T antigen induced mammary tumors [AKXD x PyMT]

Project description:Mouse genetic crosses were established between the PyMT model of metastatic breast cancer and AKXD strain. Tumors were harvested from the animals for gene expression analysis to identify genes and network modules associated with progression to distant metastatic disease. Gene expression of 56 samples from the AKXD crosses were assayed on Affymetrix chips

2011-07-21 | E-GEOD-30864 | biostudies-arrayexpress

Gene expression of polyoma middle T antigen induced mammary tumors

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Expression data from mammary tumors from a Diversity Outcross x PyMT mouse cross

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Effect of Sirolimus treatment on lupus nephritis in NZB/W F1 female mice

Project description:NZB/WF1 female mice spontaneously develop autoimmune lupus nephritis. Expression profiling of kidney tissue from (a) 12 week NZB/W F1 female mice defined as asymptomatic for lupus nephritis, (b) 36 and 42 week NZB/W F1 female mice defined as diseased/symptomatic for lupus nephritis and (c) 36 and 42 week NZB/W F1 female mice that are diseased/symptomatic for lupus nephritis and treated with Sirolimus was carried out. The goal of the study was to identify genes associated with lupus nephritis and modulated by Sirolimus, an inhibitor of mTOR. In addition, lupus nephritis genes resistant to Sirolimus therapy were also identfied This series of samples comprises of kidney tissue from (a) 12 week old NZB/W F1 female mice defined as asymptomatic for lupus nephritis (N=4), (b) 36 (N=3) and 42 week (N=3) old NZB/W F1 female mice defined as diseased/symptomatic for lupus nephritis and (c) 36 (N=3)and 42 (N=3) week old NZB/W F1 female mice that are asymptomatic for lupus nephritis on treatment with Sirolimus

2008-11-20 | E-GEOD-12024 | biostudies-arrayexpress

Effect of Sirolimus treatment on lupus nephritis in NZB/W F1 female mice

2008-11-21 | GSE12024 | GEO

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