Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Role and function of Bach2 in BCR-ABL1 driven pre-B ALL

ABSTRACT: In order to investigate the function of Bach2 in pre-B ALL, we isolated bone marrow cells from wildtype and Bach2 knockout mice of C57Bl6 background and transformed them with BCR-ABL1. We compared the gene expression profiles of Bach2 wildtype and knockout pre-B ALL cells, both with and without imatinib treatment (2uM for 16h).

ORGANISM(S): Mus musculus

SUBMITTER: Markus Muschen 

PROVIDER: E-GEOD-30883 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The B cell-specific transcription factor BACH2 is required for affinity maturation of B cells. Here we show that Bach2-mediated activation of p53 is required for stringent elimination of pre-B cells that failed to productively rearrange immunoglobulin VH-DJH gene segments. After productive VH-DJH gene rearrangement, pre-B cell receptor signaling ends BACH2-mediated negative selection through B cell lymphoma 6 (BCL6)-mediated repression of p53. In patients with pre-B acute lymphoblastic leukemia,  ...[more]

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