CelR-mediated activation of the cellobiose-utilization gene cluster in Streptococcus pneumoniae

ABSTRACT: Comparison of the Streptococcus pneumoniae D39 celR mutant compared to D39 wild type in M17 medium+ 0.5 % (w/v) Cellobiose (CM17) The human pathogen Streptococcus pneumoniae harbors many genes encoding phosphotransferase systems (PTSs) and sugar ABC (ATP-binding cassette) transporters, including systems for the utilization of the ?-glucoside sugar cellobiose. In this study, we show that the transcriptional regulator CelR, which has previously been found to be important for pneumococcal virulence, activates the expression of the cellobiose-utilization gene cluster (cel locus) of S. pneumoniae. Expression directed by the two promoters present in the cel locus was increased in the presence of cellobiose as a sole carbon source in the medium, while expression decreased in the presence of gluc

ORGANISM(S): Streptococcus pneumoniae D39

SUBMITTER: Sulman Shafeeq 

PROVIDER: E-GEOD-30891 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress