Histone chaperone NAP1 is required for sister chromatid resolution

ABSTRACT: The fidelity of chromosome duplication through cell divisions requires timely binding and release of the cohesin. Cohesin is a ring-shaped protein complex linking newly replicated sister chromatids to ensure their appropriate transmission through mitosis. Upon commencement of mitosis cohesin is removed from DNA in two steps: first, from chromosome arms resulting in sister chromatid resolution, and, second, from centromers leading to sister chromatid segregation. As DNA of eukaryotic chromosomes is assembled into chromatin, regulation of sister chromatid cohesion-segregation may involve chromatin modifying machinery, but this link is not well understood. Here we report that H2A-H2B histone chaperone NAP1, a factor, which is primarily implicated in chromatin assembly, is required for cohesin

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Yuri Moshkin 

PROVIDER: E-GEOD-30938 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress