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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Expression data from skin biopsy samples from patients with moderate-to-severe psoriasis

ABSTRACT: A gene expression profiling sub-study was conducted in which skin biopsy samples were collected from 85 patients with moderate-to-severe psoriasis who were participating in ACCEPT, an IRB-approved Phase 3, multicenter, randomized trial. This analysis identified 4,175 probe-sets as being significantly modulated in psoriasis lesions (LS) compared with matched biopsies of non-lesional (NL) skin. Skin biopsy samples (n=170) were collected at baseline for RNA extraction and microarray analysis from 85 patients with moderate-to-severe psoriasis without receiving active psoriasis therapy.

ORGANISM(S): Homo sapiens

SUBMITTER: K Li

PROVIDER: E-GEOD-30999 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Expanding the psoriasis disease profile: interrogation of the skin and serum of patients with moderate-to-severe psoriasis.

Suárez-Fariñas Mayte M Li Katherine K Fuentes-Duculan Judilyn J Hayden Karen K Brodmerkel Carrie C Krueger James G JG

The Journal of investigative dermatology 20120705 11

Psoriasis is a complex disease with an expanding definition of its pathological features. We sought to expand/refine the psoriasis transcriptome using 85 paired lesional and non-lesional samples from a cohort of patients with moderate-to-severe psoriasis vulgaris who were not receiving active psoriasis therapy. This new analysis identified 4,175 probe sets (representing 2,725 unique known genes) as being differentially expressed in psoriasis lesions compared with matched biopsies of non-lesional ...[more]

PMID: 22763790

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