Transcription profiling of lung from a mouse model of cystic fibrosis fromB6 and Balb strains vs wild type littermates to determine strain specific differences
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ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Christina Kathleen Haston
PROVIDER: E-GEOD-3100 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Strain-dependent pulmonary gene expression profiles of a cystic fibrosis mouse model.
Haston Christina K CK Cory Sean S Lafontaine Laurie L Dorion Geneviève G Hallett Michael T MT
Physiological genomics 20060401 2
Cystic fibrosis (CF) lung disease severity is influenced by unknown genetic factors apart from the disease causative gene, cystic fibrosis transmembrane conductance regulator (CFTR). Previous studies have shown the C57BL/6J congenic Cftr(-/-) (B6 CF) mouse to develop a fibrotic lung disease compared with both CF mice of the BALB/c background and wild-type animals. In this report, gene expression profiling with microarrays was used to identify genes differentially expressed in the lungs of B6 and ...[more]
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