Mutualism between gut microbiota and the host as revealed in a comparative study of breast-fed versus formula-fed infants

ABSTRACT: On going efforts are directed at understanding the mutualism between the gut microbiota and the host in breast-fed versus formula-fed infants. Due to the lack of tissue biopsies, no investigators have performed a global transcriptional (gene expression) analysis of the developing human intestine in healthy infants. As a result, the crosstalk between the microbiome and the host transcriptome in the developing mucosal-commensal environment has not been determined. In this study, we examined the host intestinal mRNA gene expression and microbial DNA profiles in full term 3 month-old infants exclusively formula fed (FF) (n=6) or breast fed (BF) (n=6) from birth to 3 months. Host mRNA microarray measurements were performed using isolated intact sloughed epithelial cells in stool samples collec

ORGANISM(S): Homo sapiens

SUBMITTER: Jennifer Goldsby 

PROVIDER: E-GEOD-31075 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress