Overexpression of Cbx4 wild type and of a Cbx4 sumoylation mutant in human epidermal stem cells

ABSTRACT: Human epidermal stem cells transit from a slow cycling to an actively proliferating state to contribute to homeostasis. Both stem cell states differ in their cell cycle profiles but must remain guarded from differentiation and senescence. Here we show that Cbx4, a Polycomb Repressive Complex-1 (PRC1)-associated protein, maintains human epidermal stem cells slow-cycling and undifferentiated, while protecting them from senescence. Interestingly, abrogating the polycomb activity of Cbx4 impairs its anti-senescent function without affecting stem cell differentiation, indicating that differentiation and senescence are independent processes in human epidermis. Conversely, Cbx4 inhibits stem cell activation and differentiation through its SUMO ligase activity. Global transcriptome and chromatin o

ORGANISM(S): Homo sapiens

SUBMITTER: Salvador Benitah 

PROVIDER: E-GEOD-31094 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress