Transcription profiling of rat hypothalamic paraventricular (PVN)nuclei in euhydrated and dehydrated animals

ABSTRACT: The hypothalamic paraventricular (PVN) and supraoptic (SON) nuclei are important integrative structures that regulate co-ordinated responses to perturbations in cardiovascular homeostasis. Through descending projections from parvocellular neurons to the brainstem, the PVN acts as an autonomic 'premotor nucleus', regulating reflex changes in sympathetic nerve activity that are involved in blood pressure and blood volume regulation. Endocrine responses are mediated through axonal projections from SON and PVN magnocellular neurons (MCNs) to the capillaries of the posterior pituitary neural lobe. In response to dehydration, a massive release of the antidiuretic peptide hormone vasopressin (VP) into the circulation is accompanied by a dramatic functional remodelling of the HNS. We ha

ORGANISM(S): Rattus norvegicus

SUBMITTER: DAVID MURPHY 

PROVIDER: E-GEOD-3111 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress