Dynamics of intercellular and extracellular miRNAs in HUVECs co-cultured with K562 cells

ABSTRACT: MicroRNAs (miRNAs) are small (18-22 nucleotides), non-coding RNAs that suppress the translation of target mRNAs by binding to their 3` untranslated region, and regulate gene networks, helping to control cell function and phenotype. Recently, the existence of extracellular miRNAs enclosed in exosomes has raised the possibility that they play an important role in cell-cell communication. The goals of this study were to elucidate whether or not miRNAs secreted from neoplastic cells transfer into endothelial cells and works functionally active in the recipient cells. In the present study, we investigated the interaction of a leukemia cell line (K562) and human umbilical vein endothelial cells (HUVECs) using a non-contact co-culture system, and assess the expression profiles of intercellular an

ORGANISM(S): Homo sapiens

SUBMITTER: Tomohiro Umezu 

PROVIDER: E-GEOD-31114 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress