The role of Raf-1 kinase inhibitor protein in the regulation of pancreatic beta cell proliferation in mice

ABSTRACT: AIMS/HYPOTHESIS: Manoeuvres aimed at increasing beta cell mass have been proposed as regenerative medicine strategies for diabetes treatment. Raf-1 kinase inhibitor protein 1 (RKIP1) is a common regulatory node of the mitogen-activated protein kinase (MAPK) and nuclear factor κB (NF-κB) pathways and therefore may be involved in regulation of beta cell homeostasis. The aim of this study was to investigate the involvement of RKIP1 in the control of beta cell mass and function. METHODS: Rkip1 (also known as Pebp1) knockout (Rkip1 (-/-)) mice were characterised in terms of pancreatic and glucose homeostasis, including morphological and functional analysis. Glucose tolerance and insulin sensitivity were examined, followed by assessment of glucose-induced insulin secretion in isolated islets and

ORGANISM(S): Mus musculus

SUBMITTER: Jordi Altirriba 

PROVIDER: E-GEOD-31150 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress