Expression data from multiple myeloma plasma cells and mesenchymal stem cells before and after co-culture

ABSTRACT: To understand how interactions of myeloma cells with osteoclasts and mesenchymal stem cells in the bone marrow affect the clinical course of myeloma, we used microarrays to study changes in gene expression in freshly isolated myeloma plasma cells following co-cultures with osteoclasts (8 experiments) or with mesenchymal stem cells (13 experiments). Interaction with osteoclasts induced changes in the expression of 675 genes, and interaction with mesenchymal stem cells induced changes in the expression of 296 genes. Expression of only 58 genes commonly and similarly changed in both co-culture systems. Among these, we identified genes associated with overall, progression-free, and post-relapse survival, and developed survival prediction models. Gene expression data from 347 patients treated w

ORGANISM(S): Homo sapiens

SUBMITTER: Joshua Epstein 

PROVIDER: E-GEOD-31159 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress