Molecular signatures of peripheral blood mononuclear cells following chronic IFN-alpha: Relationship of OAS2 with Depression and Fatigue

ABSTRACT: Interferon (IFN)-alpha causes high rates of depression and fatigue, and is used to investigate the impact of innate immune cytokines on brain and behavior. However, little is known about transcriptional profiles of circulating immune cells during chronic IFN-alpha administration. Accordingly, genome-wide transcriptional profiling was performed on peripheral blood mononuclear cells from 21 patients with chronic hepatitis C virus either awaiting IFN-alpha therapy (n=10) or after 12 weeks of IFN-alpha treatment (n=11). Significance analysis of microarray data identified 252 up-regulated gene transcripts, the majority of which were related to IFN-alpha/antiviral or innate-immune/inflammatory signaling. Of these upregulated genes, 2'-5'-oligoadenylate synthetase 2 (OAS2) was the only gene that

ORGANISM(S): Homo sapiens

SUBMITTER: Gregory Doho 

PROVIDER: E-GEOD-31187 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress