Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: WeiPing Chen
PROVIDER: E-GEOD-31193 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Thomas Emmanuel E Gonzalez Veronica D VD Li Qisheng Q Modi Ankit A AA Chen Weiping W Noureddin Mazen M Rotman Yaron Y Liang T Jake TJ
Gastroenterology 20120113 4
<h4>Background & aims</h4>Polymorphisms in the IL28B gene have been associated with clearance of hepatitis C virus (HCV), indicating a role for type III interferons (IFNs) in HCV infection. Little is known about the function of type III IFNs in intrinsic antiviral innate immunity.<h4>Methods</h4>We used in vivo and in vitro models to characterize the role of the type III IFNs in HCV infection and analyzed gene expression in liver biopsy samples from HCV-infected chimpanzees and patients. Messeng ...[more]