Tachyzoite to bradyzoite differentiation.

ABSTRACT: Asexual development in Toxoplasma gondii is a vital aspect of the parasite's life cycle, allowing transmission and avoidance of the host immune response. Differentiation of rapidly dividing tachyzoites into slowly growing, encysted bradyzoites involves significant changes in both physiology and morphology. We generated microarrays of 4,400 Toxoplasma cDNAs, representing a minimum of 600 genes (based on partial sequencing), and used these microarrays to study changes in transcript levels during tachyzoite-to-bradyzoite differentiation. This approach has allowed us to (i) determine expression profiles of previously described developmentally regulated genes, (ii) identify novel developmentally regulated genes, and (iii) identify distinct classes of genes based on the timing and magnitude of c

ORGANISM(S): Toxoplasma gondii

SUBMITTER: Michael Cleary 

PROVIDER: E-GEOD-3120 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress