Unknown,Transcriptomics,Genomics,Proteomics

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Gene expression of polyoma middle T antigen induced mammary tumors [RNA_Seq : MOLF x PyMT]


ABSTRACT: Mouse genetic crosses were established between the PyMT model of metastatic breast cancer and MOLF strain. Tumors were harvested from the animals for gene expression analysis to identify genes and network modules associated with progression to distant metastatic disease. 30 samples from the MOLF cross were assayed using Illumina next generation sequencers

ORGANISM(S): Mus musculus

SUBMITTER: Ying Hu 

PROVIDER: E-GEOD-31223 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Integrated cross-species transcriptional network analysis of metastatic susceptibility.

Hu Ying Y   Wu Gang G   Rusch Michael M   Lukes Luanne L   Buetow Kenneth H KH   Zhang Jinghui J   Hunter Kent W KW  

Proceedings of the National Academy of Sciences of the United States of America 20120130 8


Metastatic disease is the proximal cause of mortality for most cancers and remains a significant problem for the clinical management of neoplastic disease. Recent advances in global transcriptional analysis have enabled better prediction of individuals likely to progress to metastatic disease. However, minimal overlap between predictive signatures has precluded easy identification of key biological processes contributing to the prometastatic transcriptional state. To overcome this limitation, we  ...[more]

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