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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Gene expression of polyoma middle T antigen induced mammary tumors [RNA_Seq : MOLF x PyMT]

ABSTRACT: Mouse genetic crosses were established between the PyMT model of metastatic breast cancer and MOLF strain. Tumors were harvested from the animals for gene expression analysis to identify genes and network modules associated with progression to distant metastatic disease. 30 samples from the MOLF cross were assayed using Illumina next generation sequencers

ORGANISM(S): Mus musculus

SUBMITTER: Ying Hu

PROVIDER: E-GEOD-31223 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Integrated cross-species transcriptional network analysis of metastatic susceptibility.

Hu Ying Y Wu Gang G Rusch Michael M Lukes Luanne L Buetow Kenneth H KH Zhang Jinghui J Hunter Kent W KW

Proceedings of the National Academy of Sciences of the United States of America 20120130 8

Metastatic disease is the proximal cause of mortality for most cancers and remains a significant problem for the clinical management of neoplastic disease. Recent advances in global transcriptional analysis have enabled better prediction of individuals likely to progress to metastatic disease. However, minimal overlap between predictive signatures has precluded easy identification of key biological processes contributing to the prometastatic transcriptional state. To overcome this limitation, we ...[more]

PMID: 22308418

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Gene expression of polyoma middle T antigen induced mammary tumors

Project description:This SuperSeries is composed of the following subset Series: GSE30864: Gene expression of polyoma middle T antigen induced mammary tumors [AKXD x PyMT] GSE30865: Gene expression of polyoma middle T antigen induced mammary tumors [NZB x PyMT] GSE31223: Gene expression of polyoma middle T antigen induced mammary tumors [RNA_Seq : MOLF x PyMT] Refer to individual Series

2011-07-21 | E-GEOD-30866 | biostudies-arrayexpress

Gene expression of polyoma middle T antigen induced mammary tumors [RNA_Seq : MOLF x PyMT]

Project description:Mouse genetic crosses were established between the PyMT model of metastatic breast cancer and MOLF strain. Tumors were harvested from the animals for gene expression analysis to identify genes and network modules associated with progression to distant metastatic disease.

2011-08-06 | GSE31223 | GEO

CTCF promotes RNA pol II pausing and links DNA methylation to alternative splicing

Project description:This SuperSeries is composed of the following subset Series: GSE31485: CTCF promotes RNA pol II pausing and links DNA methylation to alternative splicing [ChIP-Seq] GSE31486: CTCF promotes RNA pol II pausing and links DNA methylation to alternative splicing [RNA-Seq] Refer to individual Series

2011-10-05 | E-GEOD-31278 | biostudies-arrayexpress

Expression data from mammary tumors from a MOLF/Ei x PyMT mouse cross

Project description:Mouse genetic crosses were established between the PyMT model of metastatic breast cancer and MOLF/Ei strain. Tumors were harvested from the animals for gene expression analysis to identify genes associated with progression to distant metastatic disease. Gene expression of 134 samples from the MOLF cross were assayed on Affymetrix chips.

2013-07-06 | E-GEOD-48564 | biostudies-arrayexpress

CTCF promotes RNA pol II pausing and links DNA methylation to alternative splicing [ChIP-Seq]

Project description:The goal of this study was to investigate the role of intragenic CTCF in alternative pre-mRNA splicing through a combined CTCF-ChIP-seq and RNA-seq approach. CTCF depletion led to decreased inclusion of weak upstream exons. CTCF ChIP-seq was performed in BJAB and BL41 B cell lines and normalized relative to Rabbit Ig control IP-seq reads. RNA-seq was performed in BJAB and BL41 cells transduced with shRNA against CTCF or RFP as a control, and in untransduced cells as well.

2011-10-06 | E-GEOD-31485 | biostudies-arrayexpress

Expression data from mammary tumors from a MOLF/Ei x PyMT mouse cross

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Project description:Purpose: AURKA plays an important role in breast cancer development. Exploring the gene expression profiles regulated by AURKA will facilitate to understand the mechanism which is responsible for AURKA induced breast cancer development. Results: We found that 350 genes were significantly up-regulated during AURKA overexpression in MCF-10A cells, 346 genes were significantly down-regulated during AURKA overexpression in MCF-10A cells. Conclusions: Our study indicated that 696 differentially expressed genes might contribute to AURKA induced breast cancer development. MCF-10A cells overexpressed AURKA or the empty vector were subjected to RNA extraction. The resulted RNA samples were performed RNA-sequencing analyses of gene expression profiles.

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Differential gene regulation downstream of murine Tmem173 variants

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2016-01-03 | GSE68140 | GEO

Gene expression of polyoma middle T antigen induced mammary tumors [NZB x PyMT]

Project description:Mouse genetic crosses were established between the PyMT model of metastatic breast cancer and NZB strain. Tumors were harvested from the animals for gene expression analysis to identify genes and network modules associated with progression to distant metastatic disease. Gene expression of 68 samples from the NZB crosses were assayed on Affymetrix chips

2011-07-21 | E-GEOD-30865 | biostudies-arrayexpress

Gene expression of polyoma middle T antigen induced mammary tumors [AKXD x PyMT]

Project description:Mouse genetic crosses were established between the PyMT model of metastatic breast cancer and AKXD strain. Tumors were harvested from the animals for gene expression analysis to identify genes and network modules associated with progression to distant metastatic disease. Gene expression of 56 samples from the AKXD crosses were assayed on Affymetrix chips

2011-07-21 | E-GEOD-30864 | biostudies-arrayexpress

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