Transcriptional Alterations of Hamstring Muscle Contractures in Children with Cerebral Palsy

ABSTRACT: Cerebral palsy is primarily an upper motor neuron disease that results in a spectrum of progressive movement disorders. Secondary to the neurological lesion, muscles from patients with cerebral palsy are often spastic and form debilitating contractures that limit range of motion and joint function. With no genetic component, the pathology of skeletal muscle in cerebral palsy is a response to aberrant neurological input in ways that are not fully understood. This study was designed to gain further understanding of the skeletal muscle response to cerebral palsy using microarrays and correlating the transcriptional data with functional measures. Hamstring biopsies from gracilis and semitendinosus muscles were obtained from a cohort of patients with cerebral palsy (n=10) and typically deve

ORGANISM(S): Homo sapiens

SUBMITTER: Lucas Smith 

PROVIDER: E-GEOD-31243 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress