Notch1 mediates cell fate decisions in the mouse uterus and is critical for complete decidualization

ABSTRACT: Uterine receptivity implies a dialogue between the hormonally primed maternal endometrium and the free-floating blastocyst. Endometrial stromal cells proliferate, avert apoptosis, and undergo decidualization in preparation for implantation; however, the molecular mechanisms that underlie differentiation into the decidual phenotype remain largely undefined. The Notch family of transmembrane receptors transduce extracellular signals responsible for cell survival, cell-to-cell communication, and trans-differentiation, all fundamental processes for decidualization and pregnancy. Using a murine artificial decidualization model, pharmacological inhibition of Notch signaling by gamma-secretase inhibition resulted in significantly decreased deciduoma. Furthermore, a progesterone receptor (PR)-Cre

ORGANISM(S): Mus musculus

SUBMITTER: Damian Roqueiro 

PROVIDER: E-GEOD-31244 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress