Overcoming chemoresistance in B lymphoma cells: elucidating the role of NF-kB in caspase-independent apoptosis by transcriptomic assessment.

ABSTRACT: Although therapy responsiveness to therapy in Burkitt lymphoma (BL) is high, relapsed disease and and chemoresistance remain a clinical challenge, and complete mechanisms underlying BL chemoresistance and how it can be circumvented is yet to be fully elucidated. In this study we present data showing that chymotrypsin-like serine proteases inhibitor Nα-tosyl-L-phenylalanine chloromethylketone (TPCK) and specific NF-κB inhibitor Bay-11 7082 can induce caspase-independent apoptosis in chemoresistant BL cells. We also demonstrate that both TPCK and Bay-11 7082-treatment leads to decreased NF-κB nuclear activity and that this is associated with sensitization of chemoresistant Burkitt lymphoma cells. Furthermore we investigated global transcriptional changes induced by Bay-11 7082 and TPCK in th

ORGANISM(S): Homo sapiens

SUBMITTER: Ida Johansson 

PROVIDER: E-GEOD-31258 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress