Comparison study of glioma stem cells and adult human neural stem cells

ABSTRACT: Glioblastoma, the most common and malignant brain tumor, harbors stem-like cells that self-renew and propagate upon serial transplantation. Although they share functional, morphological and developmental similarities to adult brain neural stem cells, stem cell characteristic pathways contributing to glioblastoma stem-like cells have not been consistently determined. Towards this goal we have provided an internally coherent molecular reference that compares adult neural and glioblastoma stem cells cultivated under identical conditions. Genes dysregulated between these populations are correlated with clinical outcome in glioblastoma, and are highly expressed in embryonic and induced pluripotent stem cells. The resource yields a key role for Wnt and a core group of dysregulated pathways. We

ORGANISM(S): Homo sapiens

SUBMITTER: Cecilie Sandberg 

PROVIDER: E-GEOD-31262 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress