Gene expression changes in murine ileum during inflammation: Controls vs. intestinal schistosomiasis and TNBS-ileitis.

ABSTRACT: Background: Although a number of intestinal inflammatory conditions pertain to the ileum, whole-genome gene expression analyses on ileal inflammation in animal models are lacking to date. Therefore, we aimed to identify and characterize alterations in gene expression in the acutely inflamed ileum of two murine models of intestinal inflammation, namely intestinal schistosomiasis and TNBS-induced ileitis, using Agilent whole-genome microarrays followed by bioinformatics analysis to detect enrichment of Kyoto Encyclopedia of Genes and Genomes pathways and Gene Ontology categories. Results: When compared with healthy control mice, of almost all known mouse genes and transcripts represented on the array, intestinal schistosomiasis and TNBS-induced ileitis yielded 207 and 1417 differential gene

ORGANISM(S): Mus musculus

SUBMITTER: Leela Rani Avula 

PROVIDER: E-GEOD-31265 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress