Whole genome bisulfite sequencing of Entamoeba histolytica

ABSTRACT: Up until now, the existence of Dnmt2-mediated DNA methylation has mostly been supported by focal analyses in organisms that contain Dnmt2, but no Dnmt1 or Dnmt3 DNA methyltransferase. In these organisms, several independent studies have also provided support for a biologically important function of Dnmt2-dependent DNA methylation. For example, Dnmt2-dependent methylation in Entamoeba histolytica, the causative agent of amebic dysentery, has been connected to the parasite s virulence. However, global DNA methylation levels in Entamoeba have been found to be very low. In addition, no specific features, such as CpG-specificity and specificity for certain genetic subcompartments have been described. This distinguishes Dnmt2-dependent methylation patterns from all other known methylomes and has

ORGANISM(S): Entamoeba histolytica

SUBMITTER: Guenter Raddatz 

PROVIDER: E-GEOD-31295 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress