Unfolded Protein Response
Ontology highlight
ABSTRACT:
ORGANISM(S): Saccharomyces cerevisiae
SUBMITTER: Max Diehn
PROVIDER: E-GEOD-3130 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Degradation of proteins from the ER of S. cerevisiae requires an intact unfolded protein response pathway.
Casagrande R R Stern P P Diehn M M Shamu C C Osario M M Zúñiga M M Brown P O PO Ploegh H H
Molecular cell 20000401 4
To dissect the requirements of membrane protein degradation from the ER, we expressed the mouse major histocompatibility complex class I heavy chain H-2K(b) in yeast. Like other proteins degraded from the ER, unassembled H-2K(b) heavy chains are not transported to the Golgi but are degraded in a proteasome-dependent manner. The overexpression of H-2K(b) heavy chains induces the unfolded protein response (UPR). In yeast mutants unable to mount the UPR, H-2K(b) heavy chains are greatly stabilized. ...[more]
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