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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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MicroRNA profiling of human healthy liver and hepatocellular carcinoma

ABSTRACT: microRNA profiling of 10 human healthy liver and 9 human hepatocellular carcinoma tissues using bead-based technology microRNA expression profiling was performed using freshly frozen healthy liver and hepatocellular carcinoma tissues obtained at the time of surgical treatment. keywords: healthy liver, hepatocellular carcinoma, expression array, microRNA

ORGANISM(S): Homo sapiens

SUBMITTER: Yujin Hoshida

PROVIDER: E-GEOD-31383 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Induction of hepatocellular carcinoma by in vivo gene targeting.

Wang Pei-Rong PR Xu Mei M Toffanin Sara S Li Yi Y Llovet Josep M JM Russell David W DW

Proceedings of the National Academy of Sciences of the United States of America 20120625 28

The distinct phenotypic and prognostic subclasses of human hepatocellular carcinoma (HCC) are difficult to reproduce in animal experiments. Here we have used in vivo gene targeting to insert an enhancer-promoter element at an imprinted chromosome 12 locus in mice, thereby converting ∼1 in 20,000 normal hepatocytes into a focus of HCC with a single genetic modification. A 300-kb chromosomal domain containing multiple mRNAs, snoRNAs, and microRNAs was activated surrounding the integration site. An ...[more]

PMID: 22733778

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Homo sapiens

Project description:microRNA profiling of human healthy liver and hepatocellular carcinoma

| PRJNA145909 | ENA

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