Genome-wide study of HCFC1 binding sites and its associated transcription factors in cycling Human HeLa cells

ABSTRACT: Analysis of transcriptional regulation in human cells has implicated a large number of promoter-specific DNA-binding proteins that regulate transcription via diverse mechanisms. In some cases, these DNA-sequence-specific factors associate with intermediaries that orchestrate interactions with the chromatin-modifying enzymes. One such intermediary is HCF-1 (host-cell factor-1; HCFC1). HCF-1, first identified for its involvement in herpes-simplex virus transcription and subsequently shown to be an important cell-cycle regulator, has a poorly defined role in genome-wide transcriptional regulation. We show here, by chromatin immunoprecipitation followed by high-throughput sequence analysis (ChIP-seq), that HCF-1 is a major transcriptional start site associated factor, whose promoter associ

ORGANISM(S): Homo sapiens

SUBMITTER: Viviane Praz 

PROVIDER: E-GEOD-31417 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress