A Clinically Relevant Gene Signature in Triple-Negative and Basal-Like Breast Cancer

ABSTRACT: Current prognostic gene expression profiles for breast cancer mainly reflect proliferation status and are most useful in ER-positive cancers. Triple-negative breast cancers (TNBCs) are clinically heterogeneous, and prognostic markers and biology-based therapies are needed to better treat this disease. We assembled Affymetrix gene expression data for 579 TNBCs and performed unsupervised analysis to define metagenes that distinguish molecular subsets within TNBC. We used n=394 cases for discovery and n=185 cases for validation. Sixteen metagenes emerged that identified basal-like, apocrine and claudin-low molecular subtypes, or reflected various non-neoplastic cell populations including immune cells, blood, adipocytes, stroma, angiogenesis, and inflammation within the cancer. The expression

ORGANISM(S): Homo sapiens

SUBMITTER: Thomas Karn 

PROVIDER: E-GEOD-31519 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress