A Dicistrovirus-specific inducible antiviral response in Drosophila

ABSTRACT: The fruit fly Drosophila melanogaster is a good model to unravel the molecular mechanisms of innate immunity, and has led to some important discoveries on the sensing and signalling of microbial infections. The response of drosophila to virus infections remains poorly characterized, and appears to involve two facets. On one hand RNA interference (RNAi) involves the recognition and processing of dsRNA into small interfering (si) RNAs by the host ribonuclease Dicer-2 (Dcr-2), whereas on the other hand an inducible response controlled by the evolutionarily conserved JAK/STAT pathway contributes to the antiviral host defence. In order to clarify the contribution of the siRNA and JAK/STAT pathways to the control of viral infections, we have compared the resistance of flies wild-type or mutant f

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Jean-Luc Imler 

PROVIDER: E-GEOD-31542 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress