Rapid and robust generation of functional oligodendrocyte progenitor cells from epiblast stem cells

ABSTRACT: Stem cell biology has garnered much attention due to its potential to impact human health through disease modeling and cell replacement therapy. This is especially pertinent to myelin-related disorders such as multiple sclerosis and leukodystrophies where restoration of normal oligodendrocyte function could provide an effective treatment. Progress in myelin repair has been constrained by the difficulty in generating pure populations of oligodendrocyte progenitor cells (OPCs) in sufficient quantities. Pluripotent stem cells theoretically provide an unlimited source of OPCs but significant advances are currently hindered by heterogeneous differentiation strategies that lack reproducibility. Here we provide a platform for the directed differentiation of pluripotent mouse epiblast stem cel

ORGANISM(S): Mus musculus

SUBMITTER: Paul Tesar 

PROVIDER: E-GEOD-31562 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress