Bacillus subtilis Δ7ECF Pxyl-sigV + xylose vs Δ7ECF Pxyl-sigV - xylose , 168 + lysozyme vs 168 - lysozyme

ABSTRACT: To define the ECF sigma sigV - regulated genes during log growth phase in LB media under induction conditions for sigV The seven extracytoplasmic function (ECF) sigma (σ) factors of Bacillus subtilis are broadly implicated in resistance to antibiotics and other cell envelope stressors mediated, in part, by regulation of cell envelope synthesis and modification enzymes. We here define the regulon of σV as including at least 20 operons many of which are also regulated by σM, σX, or σW. The σV regulon is strongly and specifically induced by lysozyme and this induction is key to the intrinsic resistance of B. subtilis to lysozyme. Strains with null mutations in either sigV or in all seven ECF σ factor genes (Δ7ECF) have essentially equal increases in sensitivity to lysozyme. Induction of σV i

ORGANISM(S): Bacillus subtilis subsp. subtilis str. 168

SUBMITTER: John Helmann 

PROVIDER: E-GEOD-31563 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress