The Dynamic Architecture of Hox Gene Clusters

ABSTRACT: The spatial and temporal control of Hox gene transcription is essential for patterning the vertebrate body axis. Although this process involves changes in histone posttranslational modifications, the existence of particular three-dimensional (3D) architectures remained to be assessed in vivo. Using high-resolution chromatin conformation capture methodology, we examined the spatial configuration of Hox clusters in embryonic mouse tissues where different Hox genes are active. When the cluster is transcriptionally inactive, Hox genes associate into a single 3D structure delimited from flanking regions. Once transcription starts, Hox clusters switch to a bimodal 3D organization where newly activated genes progressively cluster into a transcriptionally active compartment. This transition in spa

ORGANISM(S): Mus musculus

SUBMITTER: Marion LELEU 

PROVIDER: E-GEOD-31570 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress