Human breast cancer cell lines: vehicle vs. BMP7 incubation

ABSTRACT: Bone morphogenetic proteins (BMPs) are members of the TGF-β superfamily of growth factors. They are known for their roles in regulation of osteogenesis and developmental processes and, in recent years, evidence has accumulated of their crucial functions in tumor biology. BMP7, in particular, has been implicated in breast cancer. However, little is known about BMP target genes in the context of tumor. We therefore explored the effects of BMP7 treatment on global gene transcription in five breast cancer cell lines during a 6-point time series. Data analysis included hierarchical clustering of differentially expressed genes, gene ontology enrichment analyses and model based clustering of temporal data. BMP7 had a strong effect on gene expression. The cellular functions most strongly affected

ORGANISM(S): Homo sapiens

SUBMITTER: Alejandra Rodriguez-Martinez 

PROVIDER: E-GEOD-31604 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress