Identification of SOX4 novel transcriptional targets.

ABSTRACT: The SOX4 gene belongs to a family of transcription factors and we previously unveiled SOX4 gene amplification and over-expression in a subset of lung cancers, indicating it may constitute a driver oncogene. Here, we searched for SOX4 transcriptional targets and investigate their involvement in lung development and carcinogenesis. We abrogated SOX4 expression in the NIH-H522 lung cancer cell line, carrying SOX4 amplification and over-expression, using an inducible short-hairpin system. Global analysis of gene expression identified about 90 genes down-regulated after SOX4 abrogation many of them related to neural development. We also demonstrated recruitment of SOX4 to many of these promoters, evidencing their nature as direct transcriptional targets of SOX4. Most of these transcripts were s

ORGANISM(S): Homo sapiens

SUBMITTER: Sandra Castillo 

PROVIDER: E-GEOD-31612 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress