Transcriptional architecture of the primate neocortex

ABSTRACT: Genome-wide transcriptional profiling allows characterization of the molecular underpinnings of neocortical organization, including cortical areal specialization, laminar cell type diversity and functional anatomy. Microarray analysis of individual cortical layers across sensorimotor and association cortices in rhesus macaque demonstrated robust and specific laminar and areal molecular signatures driven by differential expression of genes associated with specialized neuronal function. Gene expression corresponding with laminar architecture was generally similar across cortical areas, although genes with robust areal patterning were often highly laminar as well, and these patterns were more highly conserved between macaque and human as compared to mouse. Layer 4 of primate primary visual

ORGANISM(S): Macaca mulatta

SUBMITTER: Susan Sunkin 

PROVIDER: E-GEOD-31613 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress