Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: G Paolo Dotto
PROVIDER: E-GEOD-3162 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Proceedings of the National Academy of Sciences of the United States of America 20050801 32
Rho GTPases integrate control of cell structure and adhesion with downstream signaling events. In keratinocytes, RhoA is activated at early times of differentiation and plays an essential function in establishment of cell-cell adhesion. We report here that, surprisingly, Rho signaling suppresses downstream gene expression events associated with differentiation. Similar inhibitory effects are exerted by a specific Rho effector, CRIK (Citron kinase), which is selectively down-modulated with differ ...[more]