Dynamic epigenetic enhancer signatures are predictive for key transcriptional regulators associated with cellular differentiation states

ABSTRACT: Cellular differentiation is orchestrated by lineage-specific transcription factors and associates with cell type-specific epigenetic signatures. Here, we utilized stage-specific, epigenetic "fingerprints" to deduce key transcriptional regulators of a cellular differentiation process. In the model of human macrophage differentiation, we globally mapped the distribution of epigenetic enhancer marks (histone H3 lysine 4 monomethylation, histone H3 lysine 27 acetylation, and the histone variant H2AZ) and show that cell type-specific epigenetic "fingerprints" correlate with specific, de novo derived motif signatures at all differentiation stages studied (hematopoietic progenitor cell, monocyte, macrophage). We validated the novel, de novo derived, macrophage-specific enhance

ORGANISM(S): Homo sapiens

SUBMITTER: Michael Rehli 

PROVIDER: E-GEOD-31621 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress