Functions of the Mediator subunit Med31 in Candida albicans support a role in shaping species-specific gene expression.

ABSTRACT: Mediator is an essential, evolutionarily conserved co-regulator of RNA polymerase II. Studies in model yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe showed remarkably conserved roles for Mediator despite high species divergence, and thus whether Mediator contributed to establishment of species-specific gene expression programs within related fungal species remains an open question. Here we show that in the fungal pathogen Candida albicans, the Mediator middle domain subunit Med31 has a conserved role with non-pathogenic model yeasts in regulation of Ace2-dependent cytokinesis genes and stress responses, but also additional roles in the transcription of genes associated with virulence traits: genes related to filamentous growth and gene families expanded in pathogenic vs non

ORGANISM(S): Candida albicans

SUBMITTER: Andre Nantel 

PROVIDER: E-GEOD-31632 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress