Tumor Suppressor BRCA1 epigenetically controls oncogenic miRNA-155

ABSTRACT: BRCA1, a well-known breast and ovarian cancer susceptibility gene with multiple interacting partners, is predicted to have diverse biological functions. However, to date its only well-established role is in the repair of damaged DNA and cell cycle regulation. In this regard, the etiopathological study of low penetrant variants of BRCA1 provides an opportunity to uncover its other physiologically important functions. Using this rationale, we studied the R1699Q variant of BRCA1, a potentially moderate risk variant, and found that it does not impair DNA damage repair but abrogates the repression of miR-155, a bona fide oncomir. We further show that in the absence of functional BRCA1, miR-155 is up-regulated in BRCA1-deficient mouse mammary epithelial cells, human and mouse BRCA1-deficienct br

ORGANISM(S): Mus musculus

SUBMITTER: Suhwan Chang 

PROVIDER: E-GEOD-31637 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress