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Combination of a novel gene expression signature with a clinical nomogram improves the prediction of survival in high-risk bladder cancer Â

ABSTRACT: Urothelial carcinoma of the bladder is characterized by significant variability in clinical outcomes depending on stage and grade. The addition of molecular information may improve our understanding of such heterogeneity and enhance prognostic prediction. The purpose of this study was to validate and improve published prognostic signatures for high-risk bladder cancer. We evaluated microarray data from 93 bladder cancer patients managed by radical cystectomy to determine gene expression patterns associated with clinical and prognostic variables.

ORGANISM(S): Homo sapiens

SUBMITTER: Markus Riester

PROVIDER: E-GEOD-31684 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Combination of a novel gene expression signature with a clinical nomogram improves the prediction of survival in high-risk bladder cancer.

Riester Markus M Taylor Jennifer M JM Feifer Andrew A Koppie Theresa T Rosenberg Jonathan E JE Downey Robert J RJ Bochner Bernard H BH Michor Franziska F

Clinical cancer research : an official journal of the American Association for Cancer Research 20120106 5

<h4>Purpose</h4>We aimed to validate and improve prognostic signatures for high-risk urothelial carcinoma of the bladder.<h4>Experimental design</h4>We evaluated microarray data from 93 patients with bladder cancer managed by radical cystectomy to determine gene expression patterns associated with clinical and prognostic variables. We compared our results with published bladder cancer microarray data sets comprising 578 additional patients and with 49 published gene signatures from multiple canc ...[more]

PMID: 22228636

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