The Exoribonuclease Nibbler Controls 3' End Processing of MicroRNAs in Drosophila

ABSTRACT: MicroRNAs (miRNAs) are endogenous noncoding small RNAs with important roles in many biological pathways; their generation and activity are under precise regulation. Emerging evidence suggests that miRNA pathways are precisely modulated with controls at the level of transcription, processing, and stability, with miRNA deregulation linked with diseases and neurodegenerative disorders. In the Drosophila miRNA biogenesis pathway, long primary miRNA transcripts undergo sequential cleavage to release the embedded miRNAs. Mature miRNAs are then loaded into Argonaute1 (Ago1) within the RNA-induced silencing complex (RISC). Intriguingly, we found that Drosophila miR-34 displays multiple isoforms that differ at the 3M-bM-^@M-2 end, suggesting a novel biogenesis mechanism involving 3M-bM-^@M-2 end pr

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Jui-Hung Hung 

PROVIDER: E-GEOD-31689 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress