Relationship between Genome-Wide DNA Methylation and Gene Expression in Uterine Leiomyoma

ABSTRACT: Uterine leiomyomas, or fibroids, represent the most common benign tumor of the female reproductive tract. Fibroids become symptomatic in 30% of all women and up to 70% of African American women of reproductive age. Epigenetic dysregulation of individual genes has been demonstrated in leiomyoma cells; however, the in vivo genome-wide distribution of such epigenetic abnormalities, however, remains unknown. Principal Findings: We characterized and compared genome-wide DNA methylation and mRNA expression profiles in uterine leiomyoma and matched adjacent normal myometrial tissues from 18 African-American women. We found 55 genes with differential promoter methylation and concominant differences in mRNA expression in uterine leiomyoma versus normal myometrium. Eighty percent of the identified g

ORGANISM(S): Homo sapiens

SUBMITTER: Antonia Navarro 

PROVIDER: E-GEOD-31699 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress