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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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E130012A19Rik: Biomarker of Pluripotent Stem Cells

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Rossella De Cegli

PROVIDER: E-GEOD-31701 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Reverse engineering a mouse embryonic stem cell-specific transcriptional network reveals a new modulator of neuronal differentiation.

De Cegli Rossella R Iacobacci Simona S Flore Gemma G Gambardella Gennaro G Mao Lei L Cutillo Luisa L Lauria Mario M Klose Joachim J Illingworth Elizabeth E Banfi Sandro S di Bernardo Diego D

Nucleic acids research 20121123 2

Gene expression profiles can be used to infer previously unknown transcriptional regulatory interaction among thousands of genes, via systems biology 'reverse engineering' approaches. We 'reverse engineered' an embryonic stem (ES)-specific transcriptional network from 171 gene expression profiles, measured in ES cells, to identify master regulators of gene expression ('hubs'). We discovered that E130012A19Rik (E13), highly expressed in mouse ES cells as compared with differentiated cells, was a ...[more]

PMID: 23180766

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