Transcription profiling of rat liver samples from animals treated with D3T (3H-1,2-dithiole-3-thione) and controls

ABSTRACT: 3H-1, 2-dithiole-3-thione (D3T), an inducer of antioxidant and phase 2 genes, is known to enhance the detoxification of environmental carcinogens, prevent neoplasia, and to elicit other protective effects. However, a comprehensive view of the regulatory pathways induced by this compound has not yet been elaborated. Fischer F344 rats were gavaged daily for 5 days with vehicle or D3T (0.3 mmol/kg). The global changes of gene expression in liver were measured with Affymetrix RG-U34A chips. Using functional class scoring, a semi-supervised method exploring both the expression pattern and the functional annotation of the genes, the Gene Ontology classes were ranked according to the significance of the impact of D3T treatment. Two unexpected functional classes were identified for the D3T treatme

ORGANISM(S): Rattus norvegicus

SUBMITTER: Yong Huang 

PROVIDER: E-GEOD-3173 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress