Global gene expression analysis in cord blood reveals gender-specific differences in response to carcinogenic exposure in utero

ABSTRACT: Gender effects in the incidence of childhood cancers have been described but the aetiology still needs to be fully examined. Given the latent period of e.g. leukemia, its very early onset in childhood might indicate the foetal period as a critical period. We consequently hypothesize that gender-specific differences in childhood cancer incidence (males have a much higher incidence of leukaemia and lymphomas) may be due to gender-specific responses to exposure to environmental carcinogens in utero. We considered that whole genome transcriptomics analysis in cord blood may provide mechanistic insight into possible gender-specific effects of carcinogen exposure in utero. Thus, the objective of the current study was to investigate whether transcriptomic responses to dietary genotoxic and non-ge

ORGANISM(S): Homo sapiens

SUBMITTER: Kevin Hochstenbach 

PROVIDER: E-GEOD-31836 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress