Genome-wide analysis of induced expression of TBX3 in the atrial appendage of the heart and controls.

ABSTRACT: to study the effect of induced expression of TBX3 within the atrium of the heart Background: Treatment of congenital or acquired disorders of the sinus node or atrioventricular node requires insight into the molecular mechanisms for the development and homeostasis of these pacemaker tissues. In the developing heart, transcription factor TBX3 is required for pacemaker and conduction system development. Here, we explore the role of TBX3 in the adult heart and investigate whether TBX3 is able to reprogram terminally differentiated working cardiomyocytes into pacemaker cells. This would be an attractive approach in biological pacemaker formation. Methods and results: TBX3 expression was ectopically induced in cardiomyocytes of adult transgenic mice. Expression analysis revealed an efficien

ORGANISM(S): Mus musculus

SUBMITTER: Martijn Bakker 

PROVIDER: E-GEOD-31969 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress