Replication Timing in Yeast: CGH microarrays: S vs G1 cells in various stress conditions

ABSTRACT: Replication timing in Saccharomyces cerevisiae in various replication stress conditions using CGH microarrays of S vs G1 cells. Replication of the eukaryotic genomes follows a characteristic temporal program, with different regions replicating at different times in S phase. We describe a stochastic model of DNA replication that naturally explains the replication profiles of a dozen of S. cerevisiae mutants. Each profile is described by a single parameter that differ between the mutants: the ratio between the fork velocity and the typical initiation rate (the “replicon length”), while all other origin-specific parameters remain unchanged. We devise an analytical method to infer the replicon lengths from the available data, and predicted its value in different mutant backgrounds. Further exp

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Ariel Gispan 

PROVIDER: E-GEOD-32002 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress