Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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GPR120 mediates high-fat diet induced obesity

ABSTRACT: Analysis of GPR120 which play roles for the fatty acid sensor in adipose tissue. Results provide insight into the transcriptional effects caused by the loss of the GPR120 proteins and provide further insight into their functions. GPR120 KO mice and the corresponding wild-type with normal diet(ND) or high fat diet(HFD), were subjected to Affymetrix Mus musculus microarrays. Epididymal adipose tissue and liver were analyzed in triplicates.

ORGANISM(S): Mus musculus

SUBMITTER: Akira Hirasawa 

PROVIDER: E-GEOD-32095 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human.

Ichimura Atsuhiko A   Hirasawa Akira A   Poulain-Godefroy Odile O   Bonnefond Amélie A   Hara Takafumi T   Yengo Loïc L   Kimura Ikuo I   Leloire Audrey A   Liu Ning N   Iida Keiko K   Choquet Hélène H   Besnard Philippe P   Lecoeur Cécile C   Vivequin Sidonie S   Ayukawa Kumiko K   Takeuchi Masato M   Ozawa Kentaro K   Tauber Maithé M   Maffeis Claudio C   Morandi Anita A   Buzzetti Raffaella R   Elliott Paul P   Pouta Anneli A   Jarvelin Marjo-Riitta MR   Körner Antje A   Kiess Wieland W   Pigeyre Marie M   Caiazzo Roberto R   Van Hul Wim W   Van Gaal Luc L   Horber Fritz F   Balkau Beverley B   Lévy-Marchal Claire C   Rouskas Konstantinos K   Kouvatsi Anastasia A   Hebebrand Johannes J   Hinney Anke A   Scherag Andre A   Pattou François F   Meyre David D   Koshimizu Taka-aki TA   Wolowczuk Isabelle I   Tsujimoto Gozoh G   Froguel Philippe P  

Nature 20120219 7389

Free fatty acids provide an important energy source as nutrients, and act as signalling molecules in various cellular processes. Several G-protein-coupled receptors have been identified as free-fatty-acid receptors important in physiology as well as in several diseases. GPR120 (also known as O3FAR1) functions as a receptor for unsaturated long-chain free fatty acids and has a critical role in various physiological homeostasis mechanisms such as adipogenesis, regulation of appetite and food prefe  ...[more]

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