Comparative genomics of Helicobacter pylori strains associated with different clinical outcome

ABSTRACT: In this study, a whole-genome CombiMatrix Custom oligonucleotide tiling microarray with 90000 probes covering six sequenced Helicobacter pylori(H. pylori) genomes was designed and utilized for comparative genomic profiling of eight unsequenced strains isolated from patients with different gastroduodenal diseases in Heilongjiang province of China. Since significant genomic variation were found among these strains, an additional 76 H. pylori stains with different clinical outcomes isolated from various provinces of China were further tested by PCR to demonstrate this distinction. We observed several highly variable regions among strains of gastritis, gastric ulceration and gastric cancer. They are involved in genes associated with bacterial type I, type II and type III R-M system as well as

ORGANISM(S): Helicobacter pylori

SUBMITTER: yuanhai you 

PROVIDER: E-GEOD-32107 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress