Host and pathogen interaction: time course [zebrafish]

ABSTRACT: The interaction between fungal pathogen and host during infection is a complex and dynamic process. To resolve this, we chose the zebrafish model organism as the host to study C. albicans infection via systems biology approach. Transcriptome microarray data and histological analysis of surviving fish were sampled at different post-infection time points. The dynamic variations of significant genes expression profiles in C. albicans and zebrafish were concurrently analyzed by principal component analysis (PCA). The PCA results clearly indicated that the infection of C. albicans can be divided into three phases that include adhesion, invasion and damage phases. The results were highly consistent with subsequent histological analysis. Furthermore, we found the primary ontology function of gene

ORGANISM(S): Danio rerio

SUBMITTER: Yan-Yu Chen 

PROVIDER: E-GEOD-32118 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress